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Thiamine Dilaurylsulfate

What is the Thiamine Dilaurylsulfate ?

Thiamine Dilaurylsulfate is a kind of Vitamin B1 derivative, and it was produced from Thiamine hydrochloride and Sodium lauryl sulfate as raw materials. Mitsubishi Tanabe Pharma Corporation developed the Vitamin B1 derivative which were stability and non-hygroscopic for nutrient enhancement. As a result, Thiamine Dicetylsulfate and Thiamine Dilaurylsulfate were estimated safety and effective in 1956 and 1958, they were appointed as Food additive of the Food Sanitation Law of Japan. There is a unique vitamin B1 smell with a crystal of the white or crystalline powder from colorlessness both and is tasteless. Thiamine Dilaurylsulfate which was stability was added in wheat, bread, noodles as for nutrient enhancement in conjunction with the vitamins intake situation of the nation at first, and it has been used. Thiamine Dilaurylsulfate is a stability than Thiamine Dicetylsulfate, Mitsubishi Tanabe Pharma Corporation sold it by the company policy.
When Thiamine Dilaurylsulfate was appointed as Food additive of the Food Sanitation Law of Japan, it was used for nutrient enhancement. Because the nutrition situation including the vitamins of the nation was improved slowly, the use decreased as nutrient enhancement. However, in late years Thiamine Dilaurylsulfate is used as an ingredient for shelf life extension, because it has high Bacteriostatic activities against fungi and lactobacilli, as well as common bacteria.

For more details ⇒ http://vitb1ls.com/

Thiamine Dilaurylsulfate Characteristics

As an ingredient for shelf life extension

  • Can be applied to many kinds of food
  • Bacteriostatic activities at a wide range of pH
  • High bacteriostatic activities against fungi and lactobacilli, as well as common bacteria
  • Enhanced activities with NaCI, Ethanol and organic acids

As vitamin B1 fortification

  • 1g of Thiamine Dilaurylsulfate is equal to 0.413g of Vit B1 HCI

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Vitamin B1 Dilaurylsulfate (Vitagen AS2) was administered to rats at concentrations of 0.1, 0.3, 1, and 3% of the diet for 6 months. As part of safety assessments of vitamin B1 Dilaurylsulfate, a 6-month chronic toxicity study was performed by its dietary administration to rats.
No deaths occurred in the highest dose (3%) group throughout the study period. There were no abnormalities ascribable to the treatment with the test substance in terms of body weight, food consumption, or hematological, blood biochemical, or urine analytical parameters.
A slight increase in kidney weight was recorded in females of the 3% group. However, this change showed no clear correlation with dose, and there were no findings that might support renal dysfunction in the clinical pathology examinations. Histological examinations also did not reveal any findings that would correspond to the increased kidney weights. Therefore, the change was coincidental. Furthermore, in the pathological examinations of other organs, there were no toxic changes representative of degeneration in the liver or kidney, and no evidence of precancerous lesions suggestive of neoplastic growth.
Blockade of neuronal impulses, respiratory paralysis, and vitamin B2 deficiency are generally known as adverse reactions following high-dose administration of a vitamin B1 preparation. However, because no such adverse findings were noted with vitamin B1 lauryl sulfate as a vitamin B1 preparation, the present test substance is considered as unlikely to cause such reactions.
In this study, the achieved oral test substance intake per day by dietary administration was found to be 1.887 g/kg/day for males and 2.322 g/kg/day for females in the highest dose (3%) groups. These were considered to be the dose levels sufficient for assessing the safety of the test substance.
It is concluded from the above results that the no observed adverse effect level under the present study conditions was 1.887 g/kg/day for males and 2.322 g/kg/day for females.

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Minimum inhibitory concentration (MIC)

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